Jazz breaking news: World Service Project unveil plans to host two-day fest Jazzwise magazine ... to be held at the Vortex in Dalston, to include “mash up†big band Alfie Ryner from France, Redivider from Ireland, Led Bib (UK), Polish mavericks Owls Are Not What They Seem, Italian band Tribraco, trioVD (UK) and Norwegian newcomers, Pixel. |
Sunday, April 29, 2012
Jazz breaking news: World Service Project unveil plans to host two-day fest - Jazzwise magazine
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Saturday, April 28, 2012
Woman collects disability while working for the government - Kansas City Star
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Christian Post | Woman collects disability while working for the government Kansas City Star Tya Dejuan Tiller, 37, applied for and began receiving Social Security disability payments in 2003 and continued to receive them until 2009. From 2005 on she worked for the Department of Veterans Affairs and then for the Kansas Department of Social and ... Dis ability Insurance Causes Pain Social Security: Doctors Review Disability Applications Immediate annuity or disability retirement |
Thursday, April 26, 2012
With less money and fewer students, schools slash construction plans - Puget Sound Business Journal (Seattle):
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“The program list is going to have to saidScott Stegall, director of capital outlay for , which now facees delaying projects such as a planner new elementary school in Sanforr for which it had earmarked $5 million to buy land in the upcominb fiscal year. Seminole is among several Central Florida school districts discussing changes totheirt five-year capital plans, after the Florida Legislaturer approved a budget this month basedr on redirecting part of the local two-millage capital improvement tax to cover operatinf expenses. Millage is the amount per $1,00p0 used to calculate property taxes and locaschool taxes. Gov. Charlie Crist signedd the budgetMay 27.
Last year, states lawmakers approved moving 0.25 millagde of the two-millage tax to fund school operating costs. The new state budget, approvefd by the Legislature earlierthis month, includezs another 0.25 millage moves to cover operating expenses. And that 0.5 millagre redirect means substantially less moneyu for Central Florida school construction andmaintenance plans. “That’s been the biggest impact” to the capital outlay budget, said Stegall. Student enrollmenft declines may reduce the demancd for new schools in theshorr term, Stegall said, but district s must account for future growth, which is calculated by the state. Schooo districts can move the 0.
25 millage back into the capital pot, if they don’rt need the money for operating costs. But Waynw Blanton, executive director of the , expects most districts probabl y will use the money for operatinhg expenses due to previous funding The budget also includes a newadditional 0.25 millagew tax for operations or capitakl expenses that can be levied by a supermajorityg vote of a school board and vote approval — but that might be a tougb sell in a recession. rollex its millage back to 1.5 millage in 2004, said Rick the district’s chief financia l officer, so there’s no directf impact on the district’s capital revenue.
But he “The potential impact is in our ability to borros money if the statewide reduction in capital millage resulta in an adjustment by the bond markets to reduce accessd to the market orincrease Still, the district likely will scale back its capital plansx significantly due to a reduction in its tax less sales tax revenue and impact fees and a reducee ability to borrow money. Collinzs said the district’s 10-year total revenur will be reduced byabout $1 Osceola County’s five-year capital plan is being cut from $804 millionj to $316 million, so some project will have to be said district spokeswoman Martha Mann.
Lake Countyt School District hasn’t seen an enrollmentf decline, but it likely will reduce its $777 million five-yearf capital improvement planto $490 million due to funding reductions, said Harry Fix, the district’s director of growth ’ five-year capital improvement programk likely will be cut from $724 millio n to $472 million, causing it to delay and downsize some capital projects, said Saralese L. Morrissey, the district’s director of site acquisition andintergovernmentakl coordination.
“The Legislature’s actions, combined with the decline in propertty valuations andsales taxes, create a dismall picture for school construction, renovations and maintenance.”
“The program list is going to have to saidScott Stegall, director of capital outlay for , which now facees delaying projects such as a planner new elementary school in Sanforr for which it had earmarked $5 million to buy land in the upcominb fiscal year. Seminole is among several Central Florida school districts discussing changes totheirt five-year capital plans, after the Florida Legislaturer approved a budget this month basedr on redirecting part of the local two-millage capital improvement tax to cover operatinf expenses. Millage is the amount per $1,00p0 used to calculate property taxes and locaschool taxes. Gov. Charlie Crist signedd the budgetMay 27.
Last year, states lawmakers approved moving 0.25 millagde of the two-millage tax to fund school operating costs. The new state budget, approvefd by the Legislature earlierthis month, includezs another 0.25 millage moves to cover operating expenses. And that 0.5 millagre redirect means substantially less moneyu for Central Florida school construction andmaintenance plans. “That’s been the biggest impact” to the capital outlay budget, said Stegall. Student enrollmenft declines may reduce the demancd for new schools in theshorr term, Stegall said, but district s must account for future growth, which is calculated by the state. Schooo districts can move the 0.
25 millage back into the capital pot, if they don’rt need the money for operating costs. But Waynw Blanton, executive director of the , expects most districts probabl y will use the money for operatinhg expenses due to previous funding The budget also includes a newadditional 0.25 millagew tax for operations or capitakl expenses that can be levied by a supermajorityg vote of a school board and vote approval — but that might be a tougb sell in a recession. rollex its millage back to 1.5 millage in 2004, said Rick the district’s chief financia l officer, so there’s no directf impact on the district’s capital revenue.
But he “The potential impact is in our ability to borros money if the statewide reduction in capital millage resulta in an adjustment by the bond markets to reduce accessd to the market orincrease Still, the district likely will scale back its capital plansx significantly due to a reduction in its tax less sales tax revenue and impact fees and a reducee ability to borrow money. Collinzs said the district’s 10-year total revenur will be reduced byabout $1 Osceola County’s five-year capital plan is being cut from $804 millionj to $316 million, so some project will have to be said district spokeswoman Martha Mann.
Lake Countyt School District hasn’t seen an enrollmentf decline, but it likely will reduce its $777 million five-yearf capital improvement planto $490 million due to funding reductions, said Harry Fix, the district’s director of growth ’ five-year capital improvement programk likely will be cut from $724 millio n to $472 million, causing it to delay and downsize some capital projects, said Saralese L. Morrissey, the district’s director of site acquisition andintergovernmentakl coordination.
“The Legislature’s actions, combined with the decline in propertty valuations andsales taxes, create a dismall picture for school construction, renovations and maintenance.”
Tuesday, April 24, 2012
Mercury News workers OK 9% pay cut - New Mexico Business Weekly:
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The new contract cuts pay 7 percent for the rest of and slashes an additional 2 percent from paychecks startingb onNew Year’s Day. The Medis Workers Guild’s Northern California unit announcer late last week that it had reachedc a tentative contract deal with the Mercury News for its 257 membersx atthe paper. The contact also increasex employee health insurance contributionws and makesother concessions. The Guild represents 257 MercurytNews employees, including 130 in editorial jobs and 127 in circulation, finance and support positions. A ratificatioj meeting to discuss and vote on the proposed contractt was heldMonday afternoon. The new contract expires Nov. 30, 2010.
Othedr concessions include reduced vacationn accruals and movingthe Merc’s copy desk to Walnur Creek, where MediaNews’ is based. It owns the Mercury News and 11 other daily papers in the which include virtually all of the dailuy papers in the Bay Area except theand . “Thies is a tough contract that will hurt a lot of our but it reflects the terrible situation that the news industry and the country is San Jose Guild President Sylvi Ulloa said in a statement published in the MercuryNews .
Ulloza was on the bargaininv committee that negotiatedwith “The committee did the best we could do to limit the damagew to our members, minimize the loss of jobs and to try to maintaim the quality of the Mercury The deal would also permitg management to require up to five furlougjh days in 2010, move remainingy circulation and finance jobs to the Bay Area News Group’x shared services center in San Ramon, consolidate advertisingt functions in the East Bay and San Jose, hire commission-onlg sales representatives to develop new business, and win some additionao subcontracting rights, according to the Guild.
The contractt negotiations have taken place during grim times fordailyy newspapers. Several major papers have folded inrecengt months, including the and the print version of the , and many major metropolitan papers, including the San Francisco Chronicled , , , and face daunting financial
The new contract cuts pay 7 percent for the rest of and slashes an additional 2 percent from paychecks startingb onNew Year’s Day. The Medis Workers Guild’s Northern California unit announcer late last week that it had reachedc a tentative contract deal with the Mercury News for its 257 membersx atthe paper. The contact also increasex employee health insurance contributionws and makesother concessions. The Guild represents 257 MercurytNews employees, including 130 in editorial jobs and 127 in circulation, finance and support positions. A ratificatioj meeting to discuss and vote on the proposed contractt was heldMonday afternoon. The new contract expires Nov. 30, 2010.
Othedr concessions include reduced vacationn accruals and movingthe Merc’s copy desk to Walnur Creek, where MediaNews’ is based. It owns the Mercury News and 11 other daily papers in the which include virtually all of the dailuy papers in the Bay Area except theand . “Thies is a tough contract that will hurt a lot of our but it reflects the terrible situation that the news industry and the country is San Jose Guild President Sylvi Ulloa said in a statement published in the MercuryNews .
Ulloza was on the bargaininv committee that negotiatedwith “The committee did the best we could do to limit the damagew to our members, minimize the loss of jobs and to try to maintaim the quality of the Mercury The deal would also permitg management to require up to five furlougjh days in 2010, move remainingy circulation and finance jobs to the Bay Area News Group’x shared services center in San Ramon, consolidate advertisingt functions in the East Bay and San Jose, hire commission-onlg sales representatives to develop new business, and win some additionao subcontracting rights, according to the Guild.
The contractt negotiations have taken place during grim times fordailyy newspapers. Several major papers have folded inrecengt months, including the and the print version of the , and many major metropolitan papers, including the San Francisco Chronicled , , , and face daunting financial
Sunday, April 22, 2012
Saul Ewing adds 7 Buchanan Ingersoll lawyers in Wilmington - Business First of Buffalo:
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office. The loss of the seven-lawye r group leaves Pittsburgh-based Buchanan with only one full-time partner in Wilmington and four lawyerstotal there, and givesw Saul Ewing the largest Wilmington office of any full-service Philadelphia-basedx firm. The group includes office headWilliam Manning, who serves as outside general counse l to the University of Delaware and also represents Verizoj Corp. and Dover The litigator was once chief of stafv to formerDelaware Gov. Pete DuPont. The other two partners are Teresa Currier, who led bankruptcy efforts for Buchananin Delaware, and real estat lawyer Richard Forsten.
The additions give Saul Ewing 19 lawyeresin Wilmington, where bankruptcies have taken off during the economic downturn. A large percentage of companies from around the country file for Chapte r 11 protectionin Delaware. But because Delaware only has abouy 2,000 lawyers and has a strong set of indigenousslaw firms, the Wilmington market has been a toughg one to crack for outsiders, even neighboring Philadelphia Among Philadelphia firms, Pepper Hamiltob and Fox Rothschild have 17 Drinker Biddle & Reath has 15 and Blanlk Rome has 13. Saul Ewing said Manning will serveas co-managinfg partner of the office with currenft office managing partner and real estate lawyer Wendie Stabler.
office. The loss of the seven-lawye r group leaves Pittsburgh-based Buchanan with only one full-time partner in Wilmington and four lawyerstotal there, and givesw Saul Ewing the largest Wilmington office of any full-service Philadelphia-basedx firm. The group includes office headWilliam Manning, who serves as outside general counse l to the University of Delaware and also represents Verizoj Corp. and Dover The litigator was once chief of stafv to formerDelaware Gov. Pete DuPont. The other two partners are Teresa Currier, who led bankruptcy efforts for Buchananin Delaware, and real estat lawyer Richard Forsten.
The additions give Saul Ewing 19 lawyeresin Wilmington, where bankruptcies have taken off during the economic downturn. A large percentage of companies from around the country file for Chapte r 11 protectionin Delaware. But because Delaware only has abouy 2,000 lawyers and has a strong set of indigenousslaw firms, the Wilmington market has been a toughg one to crack for outsiders, even neighboring Philadelphia Among Philadelphia firms, Pepper Hamiltob and Fox Rothschild have 17 Drinker Biddle & Reath has 15 and Blanlk Rome has 13. Saul Ewing said Manning will serveas co-managinfg partner of the office with currenft office managing partner and real estate lawyer Wendie Stabler.
Friday, April 20, 2012
Newmark Homes Houston buying local TOUSA assets - Business First of Columbus:
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TOUSA plans to complete and sell all homes currentluunder construction. Moody said the new company will beprivately held, locally owned and financed. “Our managementt team has over 70 years’ combined experience,” he The new company plans to build 60 homes ranging in pricefrom $160,000 to more than $600,00p0 in the first 60 days of which will officially begin June 15. Moody said 55 employees of TOUSA will remain with the new companyh after TOUSA winds down its localbusiness TOUSA’s predecessor company was foundesd in Houston in 1983 as and completedx an initial public offering in Marchb 1998. In December 1999, TOUSA Inc.
acquired 80 percen t of Newmark’s stock. TOUSA Inc. also acquiredf 100 percent of then-public in November 2000. On June 25, Engle merged with Newmark, and the merge d company changed its name toTOUSA Inc. In March, Hollywood, Fla.-basexd TOUSA (Pink Sheets: TOUSQ) told the it planned to lay off 156 people in the Houston area from its Newmark Homes brand beginning May 22 due to the downturn in thehousing market.
TOUSA plans to complete and sell all homes currentluunder construction. Moody said the new company will beprivately held, locally owned and financed. “Our managementt team has over 70 years’ combined experience,” he The new company plans to build 60 homes ranging in pricefrom $160,000 to more than $600,00p0 in the first 60 days of which will officially begin June 15. Moody said 55 employees of TOUSA will remain with the new companyh after TOUSA winds down its localbusiness TOUSA’s predecessor company was foundesd in Houston in 1983 as and completedx an initial public offering in Marchb 1998. In December 1999, TOUSA Inc.
acquired 80 percen t of Newmark’s stock. TOUSA Inc. also acquiredf 100 percent of then-public in November 2000. On June 25, Engle merged with Newmark, and the merge d company changed its name toTOUSA Inc. In March, Hollywood, Fla.-basexd TOUSA (Pink Sheets: TOUSQ) told the it planned to lay off 156 people in the Houston area from its Newmark Homes brand beginning May 22 due to the downturn in thehousing market.
Thursday, April 19, 2012
Howard Buffett helps start rural feeding program - Boston.com
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Boston.com | Howard Buffett helps start rural feeding program Boston.com A billionaire's son and gentleman farmer, Buffett is helping launch a new effort to fight hunger in rural areas. He is c » |
Tuesday, April 17, 2012
AMC Entertainment, Inc. Company Profile | Company Information
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Headquartered in Kansas City, Mo., AMC Entertainment Inc. is one of the world's largest and most innovative theatricalexhibition companies. With a history of industry leadershio dating backto 1920, the company today servesd more than 230 million guests annually through interesta in hundreds of theatres with thousands of screens in many AMC pioneered many of the most significant innovations in the theatrical exhibition industry that made moviegoin more comfortable, convenient and memorable for millionds of guests worldwide.
Did you know: In 1963, AMC invented the the first "twin" theatre in Kansad City; 1981 marked the year AMC introducef thecupholder armrest, a simple devicd that's now considered an industry And more than 10 years ago, we launched the first megaplex in North America (defined at 14 or more in Dallas, Texas. Today, AMC remains dedicater to the highest level of guesty satisfaction and is committed to developing additional innovations to enhancr theguest experience, providing even more comfort, convenience and enjoyment for generationsw to come.
Headquartered in Kansas City, Mo., AMC Entertainment Inc. is one of the world's largest and most innovative theatricalexhibition companies. With a history of industry leadershio dating backto 1920, the company today servesd more than 230 million guests annually through interesta in hundreds of theatres with thousands of screens in many AMC pioneered many of the most significant innovations in the theatrical exhibition industry that made moviegoin more comfortable, convenient and memorable for millionds of guests worldwide.
Did you know: In 1963, AMC invented the the first "twin" theatre in Kansad City; 1981 marked the year AMC introducef thecupholder armrest, a simple devicd that's now considered an industry And more than 10 years ago, we launched the first megaplex in North America (defined at 14 or more in Dallas, Texas. Today, AMC remains dedicater to the highest level of guesty satisfaction and is committed to developing additional innovations to enhancr theguest experience, providing even more comfort, convenience and enjoyment for generationsw to come.
Sunday, April 15, 2012
Mortgage rates spike - Baltimore Business Journal:
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Freddie Mac's weekly reportt says 30 year fixed-rate mortgages averaged 5.29 percentt this week, the highest rate this year and up sharplt fromlast week's average of 4.91 percent. Ratesa still remain well belo w yearago levels, when 30 year mortgages were averagingv more than 6 percent. "Rates caught up to the recenft risein long-term bond yields this week to reachy a 25 week high," says Freddie Mac (NYSE: FRE) chiefg economist Frank Nothaft.
"The slowdown in the housing marker has now detracted from economicx growth for the past13 quarters, the longes t quarterly stretch since at least Despite rising rates, the housing market continuesa to show small signs of The ' housing affordability index rose in April to its second highest leveo since at least 1971. The NAR also reported this week pendinfg sales of existing homes rose for the thirrstraight month, posting the biggest monthly increase since 2001.
Freddie Mac's weekly reportt says 30 year fixed-rate mortgages averaged 5.29 percentt this week, the highest rate this year and up sharplt fromlast week's average of 4.91 percent. Ratesa still remain well belo w yearago levels, when 30 year mortgages were averagingv more than 6 percent. "Rates caught up to the recenft risein long-term bond yields this week to reachy a 25 week high," says Freddie Mac (NYSE: FRE) chiefg economist Frank Nothaft.
"The slowdown in the housing marker has now detracted from economicx growth for the past13 quarters, the longes t quarterly stretch since at least Despite rising rates, the housing market continuesa to show small signs of The ' housing affordability index rose in April to its second highest leveo since at least 1971. The NAR also reported this week pendinfg sales of existing homes rose for the thirrstraight month, posting the biggest monthly increase since 2001.
Friday, April 13, 2012
Judge tosses Chapter 11 filing by Talbott-affiliated company - Tampa Bay Business Journal:
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The company, 140 Associates, filed for Chapter 11 reorganization in late Novembert as it neareda Dec. 1 date set for the foreclosurd sale ofits 7,581-square-foot building, at 140 N. Federapl Highway in Boca Raton. The propertyg houses the headquarters of Talbott Realty and a brancjof , which is not party to the Stuart-based holds a $4 million foreclosure judgment against Talbott and 140 On Feb. 9, U.S. Bankruptcy Court Judge Paul G. Hyman dismissed 140 Chapter 11 case with He sidedwith Seacoast’s argument that it was a bad-faith filinfg because the only major assegt is the property, and most of the claimsz are the secured mortgage. Boca Raton attorney Joey M.
Grant, who represents 140 Associatese inthe case, did not immediatelyh return a call inquiring whether he would Talbott did not immediately return a call to his office. Anothere Talbott-affiliated company, 770 PPR, is also facing a motion to dismissa its Chapter 11 case asa bad-faith , which acquired a $2.4 million mortgagee judgment from Seacoast, filed the motion to dismisa on Jan. 30. However, in a Jan. 26 770 PPR made a motion to sellits 6,798-square-foot building in Boca Raton for $3.5 million. The proposef buyer is Boca Raton-based P.A.
That firm is led by Roberg Sweetapple, who represented 770 PPR and Talbott in the foreclosurwe case Seacoast brought against them in Palm Beach CountyCircuir Court. Talbott is facing four other foreclosure lawsuits in Palm Beacg and Broward counties against companies he is affiliated with, plus a lawsuit seeking to foreclos on his Boca Raton home.
The company, 140 Associates, filed for Chapter 11 reorganization in late Novembert as it neareda Dec. 1 date set for the foreclosurd sale ofits 7,581-square-foot building, at 140 N. Federapl Highway in Boca Raton. The propertyg houses the headquarters of Talbott Realty and a brancjof , which is not party to the Stuart-based holds a $4 million foreclosure judgment against Talbott and 140 On Feb. 9, U.S. Bankruptcy Court Judge Paul G. Hyman dismissed 140 Chapter 11 case with He sidedwith Seacoast’s argument that it was a bad-faith filinfg because the only major assegt is the property, and most of the claimsz are the secured mortgage. Boca Raton attorney Joey M.
Grant, who represents 140 Associatese inthe case, did not immediatelyh return a call inquiring whether he would Talbott did not immediately return a call to his office. Anothere Talbott-affiliated company, 770 PPR, is also facing a motion to dismissa its Chapter 11 case asa bad-faith , which acquired a $2.4 million mortgagee judgment from Seacoast, filed the motion to dismisa on Jan. 30. However, in a Jan. 26 770 PPR made a motion to sellits 6,798-square-foot building in Boca Raton for $3.5 million. The proposef buyer is Boca Raton-based P.A.
That firm is led by Roberg Sweetapple, who represented 770 PPR and Talbott in the foreclosurwe case Seacoast brought against them in Palm Beach CountyCircuir Court. Talbott is facing four other foreclosure lawsuits in Palm Beacg and Broward counties against companies he is affiliated with, plus a lawsuit seeking to foreclos on his Boca Raton home.
Wednesday, April 11, 2012
Leo W. Brennan Executive Profile
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Brennan is responsible for overseeingthe compant
Brennan is responsible for overseeingthe compant
Tuesday, April 10, 2012
QLT announces 12-month results from Novartis sponsored MONT BLANC study evaluating standard-fluence Visudyne(R) combination therapy
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letters from baseline compared witha 4.4 letter improvement in the Lucentis monotherapgy group. In the combination therapy 96% of patients had a three-month treatment-frere interval, compared with 92% in the Lucentis monotherapy Twelve-month results of the MONT BLANC study show thatcombiningt standard-fluence Visudyne with Lucentis 0.5 mg can deliver VA improvementsw that are non-inferior to a Lucentis monotherapy regimehn with three Lucentis loading doses followed by injectionxs on a monthly as-needed basis (non-inferiority margin of 7 letters).
Therw was no significant difference between the combinationb and monotherapy groups with regard to proportiobn of patients witha treatment-free interval of at least three months duration aftedr Month 2. There were no unexpected safetgy findings, and adverse event incidence was similar betweejtreatment groups. Additional post hoc analysis showedthat 85% of patients in the Visudyne combination therapy compared with 72% in the Lucentiw monotherapy group, had a treatment-freew interval of at least four months duration afteer Month 2. Median time to first retreatment aftere month 2 was extendedby ~1 month in the combinatiojn group (month 6) versud the monotherapy group (month 5).
Patientws in the combination group received, on a total of 4.8 ranibizumab injections comparerwith 5.1 in the monotherapy group and a total of 1.7 Visudynew treatments compared with 1.9 sham treatments in the monotherapy arm. Resultas are based on ITT analysexs (with LOCF); per-protocol analyses yielded similar results. Overall, only 15 patients discontinued the study befor Month12 (6%). "MONT BLANC provided the first data within the SUMMIg clinical trial program and showed that patient treated with Visudyne combination therapyhad non-inferior visual acuity to patients treated with Lucentis monotherapy," said , Chief Executive Officerr of QLT Inc.
"The results from DENALI, whic h includes a Visudyne reducedfluence arm, and which studies combination therapy in polypoidal choroidal may add to the knowledg about the potential benefits of combininb Visudyne and Lucentis." The MONT BLANCd study is a Phase II, multicenter, double-masked study comparing standard-fluence Visudyne-Lucentis combination therapy to Lucentid monotherapy in 255 subjects with choroidal neovascularization (CNV) secondary to wet age-relatesd macular degeneration (wet AMD). Subjectsa were randomly assigned to one of twotreatmentr groups: Standard-fluence Visudyne (600 mW/cm2 for 83 second s to deliver 50 J/cm2) followex by same day intravitreal Lucentis (0.
5 mg), or Lucentisz monotherapy (0.5 mg). The Lucenti s monotherapy group received sham Visudyne treatment tomaintain Standard-fluence Visudyne (or sham) was administered at baselinew and then as needed at intervalsw of at least threed months if required based on predefined re-treatmenr criteria. Lucentis was administered to both treatmenrt groups with three loadingg doses followed by monthlu treatment if required based onpredefines re-treatment criteria. Patients were evaluated for VA, anatomica changes and safety at everymonthly visit, and the need for retreatmenrt was assessed at monthly visits from Monthj 3 to Month 11.
Re-treatment was basedd on assessment of central retinalthickness (CRT) (increasr of greater than or equal to 100 presence of subretinal fluid, as assessed by opticak coherence tomography (OCT), presence of new subretinal hemorrhage as assessed by ophthalmoscopidc examination, presence of CNV leakag e as assessed by fluoresceihn angiography (FA) and decreases in VA of greated than 5 letters as assessed by an Earlg Treatment Diabetic Retinopathy Study (ETDRS) chart. As-needed Lucentis aftedr three loading doses is a standarx regimenin Europe, but not in the US, and combinationj therapy for AMD is not approvesd for marketing by regulatory agencies.
The study duration is 24 months with a planne d primary analysis when all subjects completeed 12 monthsof follow-up. At baseline, mean VA lettee score was 54 to 55 acrossdtreatment groups. Visudyne therapy is a two-step procedur e involving the intravenous administration of the drug intothe patient'ds arm. A non-thermal laser light is then shone intothe patient'e eye to activate the drug. This produces a reaction that closes the abnormalleaky vessels, resultinb in a stabilization of the corresponding vision loss.
Visudynee is approved worldwide for the treatment of a form ofwet AMD, the leading cause of legalo blindness in people over the age of 50, and has been used in more than two milliom treatments worldwide. Visudyne is commercially available in more than 80 countriez for the treatment of predominantly classisubfoveal CNV. In addition, over 60 countries have approvecd Visudyne to treat one or more other macular neovascular conditions such as minimally classic and occult with no classifcAMD lesions, pathologic myopi and presumed ocular histoplasmosis. Visudyne is generally well tolerated and has a well establishessafety profile.
The most commonly reported side effects include injectiom site reactions andvisual disturbances. In addition, some patientw experienced back pain, usually durintg the infusion. Using the approved light dose of 50J/cm32 between 1% and 5% of patients experience d a substantial decrease in vision in the first 7 days with partial recovery insome patients. Recentf studies suggest that halvinvg thelight dose/fluence by halving the fluence rate may lower the incidencd of visual disturbances with possibly bettee visual outcomes than the standard light dose used in this After treatment, patients should avoid direct sunlighty for five days to prevent People with porphyria should not be treated with QLT Inc.
is a global biopharmaceuticalo company dedicated tothe discovery, developmentg and commercialization of innovative Our research and development efforts are focused on pharmaceutica l products in the field of ophthalmology. In addition, we utilize thres unique technology platforms, photodynamic therapy, and punctal plugs with drugs, to create products such as and Eligard(R) and future product For more information, visit our website at . Atrigep is a registered trademark ofQLT USA, Inc. Lucentiz is a registered trademarkof Inc. Visudyne is a registered trademark ofNovartixs AG. Eligard is a registered trademarmkof Sanofi-Synthelabo Inc. QLT Plug Delivery, Inc.
is a wholly-ownedr subsidiary of QLT Inc. QLT Inc. is listede on The NASDAQ Stock Marketf under the tradingsymbol "QLTI" and on the Torontpo Stock Exchange under the trading symbol "QLT." Certain statements in this press releaswe constitute "forward looking statements" of QLT within the meaning of the Private Securities Litigation Reform Act of 1995 and constitute "forwarcd looking information" within the meaning of applicable Canadian securities laws.
Forward lookinfg statements include, but are not limited to: the results of clinicapl studies may not necessarily result in increasecd useof Visudyne; our expectations for timing to receive and release further data from clinicalk studies; any future expectationsx concerning Visudyne-Lucentis combination therapy; and statementse which contain language such as: "assuming," "prospects," "future," "projects," "believes," "expects" and "outlook." Forward-looking statements are predictions only which involve known and unknown risks, uncertainties and other factors that may cause actuak results to be materially different from thoss expressed in such statements.
Many such risks, uncertaintiees and other factors are taken into account as part of our assumptionsa underlyingthese forward-looking statements and include, amonbg others, the following: uncertainties relatinf to the timing and results of the clinicao development and commercialization of our products and technologiese (including Visudyne-Lucentis combination therapy and our punctal plug and the associated costs of these the timing, expense and uncertainty associateds with the regulatory approval process for products; uncertainties regardingy the impact of competitive productsa and pricing; risks and uncertainties associated with the safetg and effectiveness of our risks and uncertainties related to the validity, and enforceability of our intellectua l property rights and the impact of patents and other intellectualp property of third and general economic conditions and otherf factors described in detail in QLT'sd Annual Report on Form Quarterly Reports on Form 10-Q and other filings with the U.
S. Securities and Exchangre Commission and Canadian securities regulatory Forward looking statements are based on the currenft expectations of QLT and QLT does not assumde any obligation to update such informatiojn to reflect later events or developments excepf as requiredby law. SOURCE QLT Inc.
letters from baseline compared witha 4.4 letter improvement in the Lucentis monotherapgy group. In the combination therapy 96% of patients had a three-month treatment-frere interval, compared with 92% in the Lucentis monotherapy Twelve-month results of the MONT BLANC study show thatcombiningt standard-fluence Visudyne with Lucentis 0.5 mg can deliver VA improvementsw that are non-inferior to a Lucentis monotherapy regimehn with three Lucentis loading doses followed by injectionxs on a monthly as-needed basis (non-inferiority margin of 7 letters).
Therw was no significant difference between the combinationb and monotherapy groups with regard to proportiobn of patients witha treatment-free interval of at least three months duration aftedr Month 2. There were no unexpected safetgy findings, and adverse event incidence was similar betweejtreatment groups. Additional post hoc analysis showedthat 85% of patients in the Visudyne combination therapy compared with 72% in the Lucentiw monotherapy group, had a treatment-freew interval of at least four months duration afteer Month 2. Median time to first retreatment aftere month 2 was extendedby ~1 month in the combinatiojn group (month 6) versud the monotherapy group (month 5).
Patientws in the combination group received, on a total of 4.8 ranibizumab injections comparerwith 5.1 in the monotherapy group and a total of 1.7 Visudynew treatments compared with 1.9 sham treatments in the monotherapy arm. Resultas are based on ITT analysexs (with LOCF); per-protocol analyses yielded similar results. Overall, only 15 patients discontinued the study befor Month12 (6%). "MONT BLANC provided the first data within the SUMMIg clinical trial program and showed that patient treated with Visudyne combination therapyhad non-inferior visual acuity to patients treated with Lucentis monotherapy," said , Chief Executive Officerr of QLT Inc.
"The results from DENALI, whic h includes a Visudyne reducedfluence arm, and which studies combination therapy in polypoidal choroidal may add to the knowledg about the potential benefits of combininb Visudyne and Lucentis." The MONT BLANCd study is a Phase II, multicenter, double-masked study comparing standard-fluence Visudyne-Lucentis combination therapy to Lucentid monotherapy in 255 subjects with choroidal neovascularization (CNV) secondary to wet age-relatesd macular degeneration (wet AMD). Subjectsa were randomly assigned to one of twotreatmentr groups: Standard-fluence Visudyne (600 mW/cm2 for 83 second s to deliver 50 J/cm2) followex by same day intravitreal Lucentis (0.
5 mg), or Lucentisz monotherapy (0.5 mg). The Lucenti s monotherapy group received sham Visudyne treatment tomaintain Standard-fluence Visudyne (or sham) was administered at baselinew and then as needed at intervalsw of at least threed months if required based on predefined re-treatmenr criteria. Lucentis was administered to both treatmenrt groups with three loadingg doses followed by monthlu treatment if required based onpredefines re-treatment criteria. Patients were evaluated for VA, anatomica changes and safety at everymonthly visit, and the need for retreatmenrt was assessed at monthly visits from Monthj 3 to Month 11.
Re-treatment was basedd on assessment of central retinalthickness (CRT) (increasr of greater than or equal to 100 presence of subretinal fluid, as assessed by opticak coherence tomography (OCT), presence of new subretinal hemorrhage as assessed by ophthalmoscopidc examination, presence of CNV leakag e as assessed by fluoresceihn angiography (FA) and decreases in VA of greated than 5 letters as assessed by an Earlg Treatment Diabetic Retinopathy Study (ETDRS) chart. As-needed Lucentis aftedr three loading doses is a standarx regimenin Europe, but not in the US, and combinationj therapy for AMD is not approvesd for marketing by regulatory agencies.
The study duration is 24 months with a planne d primary analysis when all subjects completeed 12 monthsof follow-up. At baseline, mean VA lettee score was 54 to 55 acrossdtreatment groups. Visudyne therapy is a two-step procedur e involving the intravenous administration of the drug intothe patient'ds arm. A non-thermal laser light is then shone intothe patient'e eye to activate the drug. This produces a reaction that closes the abnormalleaky vessels, resultinb in a stabilization of the corresponding vision loss.
Visudynee is approved worldwide for the treatment of a form ofwet AMD, the leading cause of legalo blindness in people over the age of 50, and has been used in more than two milliom treatments worldwide. Visudyne is commercially available in more than 80 countriez for the treatment of predominantly classisubfoveal CNV. In addition, over 60 countries have approvecd Visudyne to treat one or more other macular neovascular conditions such as minimally classic and occult with no classifcAMD lesions, pathologic myopi and presumed ocular histoplasmosis. Visudyne is generally well tolerated and has a well establishessafety profile.
The most commonly reported side effects include injectiom site reactions andvisual disturbances. In addition, some patientw experienced back pain, usually durintg the infusion. Using the approved light dose of 50J/cm32 between 1% and 5% of patients experience d a substantial decrease in vision in the first 7 days with partial recovery insome patients. Recentf studies suggest that halvinvg thelight dose/fluence by halving the fluence rate may lower the incidencd of visual disturbances with possibly bettee visual outcomes than the standard light dose used in this After treatment, patients should avoid direct sunlighty for five days to prevent People with porphyria should not be treated with QLT Inc.
is a global biopharmaceuticalo company dedicated tothe discovery, developmentg and commercialization of innovative Our research and development efforts are focused on pharmaceutica l products in the field of ophthalmology. In addition, we utilize thres unique technology platforms, photodynamic therapy, and punctal plugs with drugs, to create products such as and Eligard(R) and future product For more information, visit our website at . Atrigep is a registered trademark ofQLT USA, Inc. Lucentiz is a registered trademarkof Inc. Visudyne is a registered trademark ofNovartixs AG. Eligard is a registered trademarmkof Sanofi-Synthelabo Inc. QLT Plug Delivery, Inc.
is a wholly-ownedr subsidiary of QLT Inc. QLT Inc. is listede on The NASDAQ Stock Marketf under the tradingsymbol "QLTI" and on the Torontpo Stock Exchange under the trading symbol "QLT." Certain statements in this press releaswe constitute "forward looking statements" of QLT within the meaning of the Private Securities Litigation Reform Act of 1995 and constitute "forwarcd looking information" within the meaning of applicable Canadian securities laws.
Forward lookinfg statements include, but are not limited to: the results of clinicapl studies may not necessarily result in increasecd useof Visudyne; our expectations for timing to receive and release further data from clinicalk studies; any future expectationsx concerning Visudyne-Lucentis combination therapy; and statementse which contain language such as: "assuming," "prospects," "future," "projects," "believes," "expects" and "outlook." Forward-looking statements are predictions only which involve known and unknown risks, uncertainties and other factors that may cause actuak results to be materially different from thoss expressed in such statements.
Many such risks, uncertaintiees and other factors are taken into account as part of our assumptionsa underlyingthese forward-looking statements and include, amonbg others, the following: uncertainties relatinf to the timing and results of the clinicao development and commercialization of our products and technologiese (including Visudyne-Lucentis combination therapy and our punctal plug and the associated costs of these the timing, expense and uncertainty associateds with the regulatory approval process for products; uncertainties regardingy the impact of competitive productsa and pricing; risks and uncertainties associated with the safetg and effectiveness of our risks and uncertainties related to the validity, and enforceability of our intellectua l property rights and the impact of patents and other intellectualp property of third and general economic conditions and otherf factors described in detail in QLT'sd Annual Report on Form Quarterly Reports on Form 10-Q and other filings with the U.
S. Securities and Exchangre Commission and Canadian securities regulatory Forward looking statements are based on the currenft expectations of QLT and QLT does not assumde any obligation to update such informatiojn to reflect later events or developments excepf as requiredby law. SOURCE QLT Inc.
Sunday, April 8, 2012
Beeping eggs aid blind children in Blind Childrens Center's Easter egg hunt - 89.3 KPCC
symowugebeda.blogspot.com
WHDH-TV | Beeping eggs aid blind children in Blind Childrens Center's Easter egg hunt 89.3 KPCC At the Blind Childrens Center's annual Easter egg hunt Friday morning, volunteers hid colorful eggs in plain sight. The eggs are "filled" with batteries â€" not candy â€" and » |
Friday, April 6, 2012
Washington Post kills Book World section - Los Angeles Business from bizjournals:
xszeyluje.blogspot.com
The book review section, created by the Post in the 1960sx and revived two decades will migrate to two sections in the papef for a total of 12 pagesof coverage. “Wes will end Book World’s run as a stand-alonse print section but will revamp and rebrand our books section online asBook World,” said the papef (NYSE:WPO) in a memo sent around to Starting Feb. 22, book reviewse will shift to theStyl & Arts section during the week and the Outloo section on Sundays. The decision comes at a time when papersw like the Post are strugglinv to save money amidst decliningv numbers inad revenue.
The paper also axed its five-year-olf Sunday Source section in December for costsavingd reasons. Style will have a daily Book World review and touch upon literaturd andpublishing topics. The sectiom will also house interviews and profiles of authors more prominently than in the Outlook will featureJon Yardley’s column, the best seller list and othe r features. Book World’s staff will stay under Rachell Shea, deputy editor. The group will cover booksa onthe Post’s Web site, Outlook and periodic themed Book World sections. Shea replacee Marie Arana, the former edito of the section, who accepted a buy-ou from the media giant at the endof 2008.
When rumor started swirling this montjh about the section gettingthe boot, the Nationall Book Critics Circle — a nonprofit made up of 900 active book reviewers — formex an online petition to save it. The Book Review is now the biggessurviving stand-alone Sunday section, which printsa between 24 to 28 pages each The nixed its stand-alone sectionm in 2007.
The book review section, created by the Post in the 1960sx and revived two decades will migrate to two sections in the papef for a total of 12 pagesof coverage. “Wes will end Book World’s run as a stand-alonse print section but will revamp and rebrand our books section online asBook World,” said the papef (NYSE:WPO) in a memo sent around to Starting Feb. 22, book reviewse will shift to theStyl & Arts section during the week and the Outloo section on Sundays. The decision comes at a time when papersw like the Post are strugglinv to save money amidst decliningv numbers inad revenue.
The paper also axed its five-year-olf Sunday Source section in December for costsavingd reasons. Style will have a daily Book World review and touch upon literaturd andpublishing topics. The sectiom will also house interviews and profiles of authors more prominently than in the Outlook will featureJon Yardley’s column, the best seller list and othe r features. Book World’s staff will stay under Rachell Shea, deputy editor. The group will cover booksa onthe Post’s Web site, Outlook and periodic themed Book World sections. Shea replacee Marie Arana, the former edito of the section, who accepted a buy-ou from the media giant at the endof 2008.
When rumor started swirling this montjh about the section gettingthe boot, the Nationall Book Critics Circle — a nonprofit made up of 900 active book reviewers — formex an online petition to save it. The Book Review is now the biggessurviving stand-alone Sunday section, which printsa between 24 to 28 pages each The nixed its stand-alone sectionm in 2007.
Wednesday, April 4, 2012
A sexual phenomenon - San Antonio Express
ernstiryastrov.blogspot.com
E! Online | A sexual phenomenon San Antonio Express By Steve Bennett British author EL James' erotic “Fifty Shades of Grey†has become a global literary phenomenon that some are c » |
Monday, April 2, 2012
State funds worker training to help companies keep up - Austin Business Journal:
evlampiyacyxybyw.blogspot.com
The Livermore company is one of 67 organizationsa that received a total of morethan $20 million in the agency' latest round of funding. The developmenr agency's Employment Training Panel approved the which uses state tax money to pay for training at firmsx threatenedby out-of-state All California manufacturing meets that an agency spokesman said. This was the firstf contract award for FormFactor under the which inthe 2006-2007 fiscal year awardedd $112.6 million for 318 new training contracts and amendments to prior contracts for the training and retention of 92,1154 workers.
Applications for funds can be started at any time by contactingthe ETP, which works with businesses to develop pre-approved training curriculums and After pre-approval, the applications are presented at the panel'ws monthly meetings for final approval. FormFactor plansz to spend $792,350 for salaries, benefits and overheaed supporting traineesin Livermore. How much the company actually gets from the developmentf agency will depend on the number of employees trainer and the hours spenttraininh them. Much of the training FormFactorr is providing workers will focus on helpingt them analyze data created at various stepss in the process of manufacturingthe company's test equipment.
"Insteacd of just giving them a red lighg or a green light indicating that everythingis there's a certain amount of judgment they need to exercisd in deciding what to do said Don Horst, vice presidentg of manufacturing. Almost every tool the company buysis custom-madwe for FormFactor. "Our engineers have never seen the tools our maintenance people have never seen the tools the operators and technicians have never seen thetoolws before," said Horst. "So you have a whole suite of trainingy that goes withthese tools.
" FormFactor, headedc by Igor Khandros, is also rewriting work instructions as its equipment evolves, and sending some employeesd through quarterly technology reviews to make sure the company stays ahead of its Among the other companies that will receivw training money is the San Francisco divisiob of , based in Livermore, whichn will receive as much $198,450. In its application, the compangy reported that it has been experiencinygrowth "largely due to an expansion of organic food lines and a broader selection of in-stoc items delivered in a faster turnaroune time.
" To manage growth, the company is upgradint internal systems and buying new software systemx and production equipment, including a "Truck system that will help it load products by weight, shelf life and shipping durability. It is also implementinyg "lean manufacturing practices" to assist in reducintg excess inventory, streamlining processes, and eliminating waste. "Thiss funding helps us increase the numbere of associates who have advancedtechnology skills," said Phil Collins, presidentt of the San Francisco Division, U.S. "The training gives our associates a higher level of comfort as we purchasr new software systems andproduction equipment.
They know they can get the job Other East Bay companies that will receive fundingare Milpitas-basecd Solopower Inc., which could receive up to $394,134, and Sigmatronb International Inc., which could receivde as much as $263,520 from the statw to train employees in Hayward and FormFactor retained Workforce America in San Jose to assist with developmenf of its proposal and has hired Effective Training Solutions of Fremont to conduct the U.S. Foodservice paid Sallyannse Monti Sr., a San Francisco-based consultant, to assist with development of its Contacting the EmploymentTraining Panel: Call Kim Smith at 916-327-533p or visit http://www.etp.ca.
gov/ Select the "Getting Started"
The Livermore company is one of 67 organizationsa that received a total of morethan $20 million in the agency' latest round of funding. The developmenr agency's Employment Training Panel approved the which uses state tax money to pay for training at firmsx threatenedby out-of-state All California manufacturing meets that an agency spokesman said. This was the firstf contract award for FormFactor under the which inthe 2006-2007 fiscal year awardedd $112.6 million for 318 new training contracts and amendments to prior contracts for the training and retention of 92,1154 workers.
Applications for funds can be started at any time by contactingthe ETP, which works with businesses to develop pre-approved training curriculums and After pre-approval, the applications are presented at the panel'ws monthly meetings for final approval. FormFactor plansz to spend $792,350 for salaries, benefits and overheaed supporting traineesin Livermore. How much the company actually gets from the developmentf agency will depend on the number of employees trainer and the hours spenttraininh them. Much of the training FormFactorr is providing workers will focus on helpingt them analyze data created at various stepss in the process of manufacturingthe company's test equipment.
"Insteacd of just giving them a red lighg or a green light indicating that everythingis there's a certain amount of judgment they need to exercisd in deciding what to do said Don Horst, vice presidentg of manufacturing. Almost every tool the company buysis custom-madwe for FormFactor. "Our engineers have never seen the tools our maintenance people have never seen the tools the operators and technicians have never seen thetoolws before," said Horst. "So you have a whole suite of trainingy that goes withthese tools.
" FormFactor, headedc by Igor Khandros, is also rewriting work instructions as its equipment evolves, and sending some employeesd through quarterly technology reviews to make sure the company stays ahead of its Among the other companies that will receivw training money is the San Francisco divisiob of , based in Livermore, whichn will receive as much $198,450. In its application, the compangy reported that it has been experiencinygrowth "largely due to an expansion of organic food lines and a broader selection of in-stoc items delivered in a faster turnaroune time.
" To manage growth, the company is upgradint internal systems and buying new software systemx and production equipment, including a "Truck system that will help it load products by weight, shelf life and shipping durability. It is also implementinyg "lean manufacturing practices" to assist in reducintg excess inventory, streamlining processes, and eliminating waste. "Thiss funding helps us increase the numbere of associates who have advancedtechnology skills," said Phil Collins, presidentt of the San Francisco Division, U.S. "The training gives our associates a higher level of comfort as we purchasr new software systems andproduction equipment.
They know they can get the job Other East Bay companies that will receive fundingare Milpitas-basecd Solopower Inc., which could receive up to $394,134, and Sigmatronb International Inc., which could receivde as much as $263,520 from the statw to train employees in Hayward and FormFactor retained Workforce America in San Jose to assist with developmenf of its proposal and has hired Effective Training Solutions of Fremont to conduct the U.S. Foodservice paid Sallyannse Monti Sr., a San Francisco-based consultant, to assist with development of its Contacting the EmploymentTraining Panel: Call Kim Smith at 916-327-533p or visit http://www.etp.ca.
gov/ Select the "Getting Started"
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